Cardiac Biomarker Detection: From Epidemiology to Clinical Applications in Heart Disease

Prevalence of Heart Diseases

Globally, approximately 17.5 million people die from heart disease and related conditions each year, accounting for 30% of all deaths. Although over 20 million people survive heart attacks or strokes annually, most of these patients still face a high risk of recurrence and mortality.

In China, approximately 2.6 million people die from cardiovascular and cerebrovascular diseases each year, ranking second globally. The high incidence of heart disease has become a significant public health issue; however, fewer than 120,000 patients receive bypass surgery or interventional treatment annually.

Notably, about 80% of sudden cardiac deaths are caused by coronary heart disease and its complications, while the remaining cases can be attributed to heart failure, valvular heart disease, congenital heart disease, etc.

Influencing Factors of Heart Diseases

1. Modifiable Factors

• Environmental factors: Air pollution, extreme temperatures, social competitive pressures
• Personal factors: Hypertension, hyperlipidemia, sleep apnea syndrome, psychological states
• Exercise factors: Lack of exercise, overweight or obesity, excessive exercise
• Lifestyle habits: Unhealthy diet, smoking behavior

2. Non-Modifiable Factors

• Age, gender, ethnicity, family history
• Certain systemic diseases (infectious diseases, respiratory diseases, digestive diseases, endocrine diseases)

Cardiac Disease-related Markers

1. Myocardial Injury Markers

• Cardiac troponin (cTnI/cTnT): Widely used clinical indicator of myocardial injury
• Creatine kinase isoenzyme MB (CK-MB): Specific marker for myocardial injury
• Myoglobin (Myo): Early marker for myocardial damage

2. Cardiac Markers

• BNP/NT-proBNP: Important for early diagnosis and prognosis evaluation of heart failure, differential diagnosis of acute chest pain

3. Coagulation Function Markers

• D-Dimer: Preferred screening indicator for acute pulmonary embolism (APE) and aortic dissection

Virtue Diagnostics Cardiac Marker Detection Solution

Combining patient characteristics and testing needs, Virtue Diagnostics has launched a POCT cardiac marker rapid detection solution: five cardiac markers (hs-cTnI/CK-MB/Myo/NT-proBNP/D-Dimer) + four inflammation markers (CRP/SAA/PCT/IL-6), completing important screening indicators within 20 minutes.

The SuperFlex® POCT chemiluminescence analyzer is based on the two characteristics of "accuracy" and "flexibility", focusing on critical illnesses, and providing timely and reliable cardiovascular and inflammation marker diagnosis for clinical departments, emergency laboratories, and central laboratories.

Product Features